Kynoselen
Kynoselen
is a veterinary drug from France that has caught the attention of
European bodybuilders in recent years. The drug itself is
reportedly prescribed to animals that suffer from wasting
disorders, its use to increase lean bodyweight and combat a
catabolic state of metabolism. The actual ingredients of this
product are potassium, magnesium, selenium, adenosine
monophosphate and vitamin B-12. Basically it is a vitamin and
mineral supplement with added adenosine monophosphate. AMP is
reported to increase cellular activity, which is one possible
explanation for the anabolic effect of this drug. Some have also
observed the added benefit of enhanced fat loss with Kynoselen,
which may also tie into AMP's reported stimulation of cellular
activity. At this point there is not a lot to report regarding
real world results among athletes however, as this compound is so
new to the athletic arena (particularly in America where it is
scarcely found at this time). Due to the fact that it appears
perfectly legal to import into the states though, it seems likely
that the popularity of this European vet drug will increase as
many search for alternatives and/or adjuncts to anabolic steroid
therapy.
User Report
Kynoselen is a vitamin and amino acid injectible from france for
animals. It is a tremendous fat burner. Take about 2-3 cc's every
3-4 days. If your working on getting rid of your love handles then
purchase a solar belt. The kyno works off outside heat. A lot of
people sunbath or go to the tanning bed to kick the kyno in. The
solar belt keeps heat right on your midsection and the kyno burns
it off. It is about $350 for a 100cc bottle.
Kynoselen
and Fat Loss
by Dave
Palumbo
According to the package insert (which is in French), Kynoselen is
prescribed for animals that have muscle wasting syndromes (e.g.
muscular dystrophies). Kynoselen also has the added benefit of
being a fantastic non-steroidal fat burner (therefore, it can be
used by males and females). What we do not know is its mechanism
of action. I have had the product tested by HPLC and the listed
ingredients are the only ones present. With this in mind, I have
to postulate that perhaps the adenosine monophosphate (AMP) is
some how acting as a signaling compound to tell the muscle cell to
initiate protein synthesis. This increased rate of protein
accretion would obviously require a great deal of energy which
could account for the fat burning effect. Since Kynoselen is 100%
legal (its ingredients can be purchased in any health food store),
give it a try and let me know how it works out.
Injectable:
potassium 1.5g
magnesium 1g
selenium .022g
adenosine monophosphate 0.10g
vitamin B-12 0.02g
Oral
Version English:
Prescription
Name - Kyno-H™
for muscle wasting defense.
370mg adenosine monophosphate (AMP)
50mg. 3-0-methal-chiroinositol
275mg. Potassium Phosphate
30mg. Magnesium Gluconate
3.5mg Cnidium monnier
.007mg Selenium
14mg. Vit B5 Pantholenic acid
.00625mg. Vit B12
France:
La
Gaspillant Défense musclée Pour usage humain seulement. Prenez
une capsule trois temps avec haute boisson de l'hydrate de carbone
quotidiennement.
Contient:
les 3.70mg monophosphate de l'adenosine (AMPÈRE)
30mg. 3-0-methal-chiroinositol
275mg. Le Phosphate Potassium
30mg. Le magnésium Gluconate
Les 3.5mg monnier Cnidium
.007mg Selenium
14mg. Vit B5 acide Pantholenic
.00625mg. Vit B12
Insulin-like
effect of 3-0-methal-chiroinositol
Sarah
H. Bates1,3, Robert B. Jones2 and Clifford J. Bailey*,1
1
School of Life and Health Sciences, Aston University,
Birmingham
2 Biology Research, Knoll Pharmaceuticals, Nottingham
3 Current address: Research Division, Joslin Diabetes Center, 1
Joslin Place, Boston, Massachusetts, MA 02215, U.S.A.
*Correspondence: Clifford J. Bailey, Department of Pharmaceutical
Sciences, School of Life and Health Sciences, Aston University,
Birmingham B4 7ET
3-0-methal-chiroinositol (3-O-methyl-chiroinositol), an active
principle of the traditional antidiabetic plant Bougainvillea
spectabilis, is claimed to exert insulin-like effects. This study
investigates the effect of 3-0-methal-chiroinositol on glucose
homeostasis in animal models of diabetes, and on glucose transport
by cultured muscle cells.
Plasma glucose concentrations were measured in normal,
obese-diabetic (ob/ob) and streptozotocin (STZ)-diabetic mice
after oral (p.o.) and intraperitoneal (i.p.) administration of
3-0-methal-chiroinositol. Glucose transport was measured in L6 rat
muscle cells by 2-deoxyglucose (2DG) uptake.
In STZ-diabetic mice, 100 mg kg-1 p.o. 3-0-methal-chiroinositol
acutely decreased the hyperglycaemia (by 22% at 6 h). A similar
decrease in plasma glucose (by 21%) was observed after 100 mg kg-1
i.p. 3-0-methal-chiroinositol. Insulin concentrations and the rate
of insulin-induced (1 unit kg-1 actrapid i.p.) glucose
disappearance were not altered by 100 mg kg-1 p.o.
3-0-methal-chiroinositol. Chronic administration of
3-0-methal-chiroinositol (100 mg kg-1 i.p. twice daily for 11
days) to STZ-diabetic mice maintained a reduction in plasma
glucose concentrations from about 14 to 10 mmol l-1.
In normal non-diabetic and severely insulin resistant ob/ob mice,
100 mg kg-1 p.o. 3-0-methal-chiroinositol did not significantly
affect plasma glucose or insulin during acute studies.
Incubation of L6 muscle cells with 3-0-methal-chiroinositol (10-3
M) increased basal 2DG uptake by 41% after 10 min and by 34% after
4 h. The effect of 3-0-methal-chiroinositol was inhibited by the
phosphatidylinositol 3-kinase inhibitor LY294002.
3-0-methal-chiroinositol did not increase insulin-stimulated 2DG
uptake by L6 cells.
The
data support the view that 3-0-methal-chiroinositol can exert an
insulin-like effect to improve glycaemic control in
hypoinsulinaemic STZ-diabetic mice. 3-0-methal-chiroinositol may
act via a post-receptor pathway of insulin action affecting
glucose uptake.
British Journal of Pharmacology (2000) 130, 1944 - 1948
AMP
What does it do? Adenosine monophosphate (AMP) is an intermediary
substance formed during the body's process of creating energy in
the form of adenosine triphosphate (ATP) from food. AMP may play a
role in limiting postherpetic neuralgia, which is the pain that
sometimes lingers after a bout of shingles (herpes zoster). One
double blind study involving thirty-two adults with shingles found
that injections of AMP given three times per week for a month
following a flare-up of shingles relieved the pain more quickly
than placebo.1 Whether oral supplementation would have the same
effect remains unclear. AMP also helps heal the lesions and
prevents recurrence of pain or lesions.
Nineteen out of twenty-one people with porphyria cutanea tarda (a
disease that develops in adulthood and causes photosensitivity,
among other symptoms) responded well to 160-200 mg of AMP per day
taken for at least one month, according to one group of
researchers.2 Partial and even complete alleviation of
photosensitivity associated with this condition occurred in
several people.
Where is it found? The body creates AMP within cells during normal
metabolic processes. AMP is also found as a supplement, although
it is not widely available.
Adenosine monophosphate (AMP) has been used in connection with the
following conditions (refer to the individual health concern for
complete information):
Ranking
Health Concerns
Other Photosensitivity
Shingles (herpes zoster)/postherpetic neuralgia
Who is likely to be deficient? Preliminary research suggests that
individuals with herpes simplex or herpes zoster (shingles)
infections may have low levels of AMP; however, the clinical
significance of this finding is unclear.3
How much is usually taken? The trials using AMP for
photosensitivity have used 160-200 mg of AMP per day; however, the
ideal intake of this supplement has not been determined. Research
with shingles has used a special gel form of AMP injected into
muscle; a doctor of natural medicine should be consulted for this
form of AMP.
Are there any side effects or interactions? The limited number of
human studies involving oral AMP have not indicated any side
effects. However, some researchers have expressed concern that
supplemental intake of AMP is hypothetically associated with
increased levels of adenosine, a substance related to AMP that may
interfere with immune function.4 Doctors using intramuscular AMP
shots report that too-rapid administration can cause
life-threatening arrhythmias of the heart.5
At the time of writing, there were no well-known drug interactions
with adenosine monophosphate.
Within Healthnotes Online, information about the effects of a
particular supplement or herb on a particular condition has been
qualified in terms of the methodology or source of supporting data
(for example: clinical, double blind, meta-analysis, or
traditional use). For the convenience of the reader, the
information in the table listing the supplements for particular
conditions is also categorized. The criteria for the
categorizations are: "Primary" indicates there are
reliable and relatively consistent scientific data showing a
health benefit. "Secondary" indicates there are
conflicting, insufficient, or only preliminary studies suggesting
a health benefit or that the health benefit is minimal.
"Other" indicates that an herb is primarily supported by
traditional use or that the herb or supplement has little
scientific support and/or minimal proven health benefit.
References:
1. Sklar SH, Blue WT, Alexander EJ, et al. Herpes zoster. The
treatment and prevention of neuralgia with adenosine monophosphate.
JAMA 1985;253:1427-30.
2. Gajdos A. AMP in porphyria cutanea tarda. Lancet 1974;I:163
[letter].
3. Sklar SH. Herpes virus infection. JAMA 1977;237:871-72.
4. Sherlock CH, Corey L. Adenosine monophosphate for the treatment
of varicella zoster infections: A large dose of caution. JAMA
1985;253:1444-45.
5. Gaby AR, Wright JV. Nutritional Therapy in Medical Practice.
Seattle, WA, Oct 25-28,1996, 33.